论文NaV1.7作为疼痛药物基因组学靶标:精准医学

Genomic analysis, together with atomic-level structural modeling and in vitro biophysical/pharmacological analysis, can predict efficacy of specific drugs in a patient-specific manner. iPSC-derived neurons may prove useful for patient-specific drug screening. Studies on inherited pain disorders may inform research on pain in broader populations. Development of a new class of isoform-selective channel blockers may enhance the treatment of pain while reducing undesirable side effects. Discovery, based on genomic analysis, of new mechanisms of drug action may lead to more effective treatment.展开>><<收起

Trends in Pharmacological Sciences,Available online 20 January 2018  0
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