Hyaluronic Acid-Coated Silver Nanoparticles As a Nanoplatform for in Vivo Imaging Applications


作者:Xin Zhang,† Meinan Yao,† Muhua Chen,† Liqiang Li,† Chengyan Dong,‡ Yi Hou,§ Huiyun Zhao,†,⊥ Bing Jia,*,†,⊥ and Fan Wang*,†,‡

ACS Appl. Mater. Interfaces 卷:0 期:8 页:25650  发表年份:2016

摘要:An efficient chemical reduction protocol has been developed for the synthesis of hyaluronic acid-coated silver nanoparticles (HA-Ag NPs) that are spherical, ultrasmall and monodisperse. The as-synthesized HA-Ag NPs not only exhibited excellent long-term stability and low cytotoxicity but also could be used as a nanoplatform for X-ray computed tomography (CT) and single-photon emission computed tomography (SPECT) imaging after being radiolabeled with 99mTc.